UPSTREAM MG
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UPSTREAM MG · WHY CONSIDER JOINING?

There are many reasons people consider a clinical study.

Some want to learn about a possible new treatment option. Others want closer study-related follow-up, or want to help future patients by contributing to research. Only you can decide whether taking part is right for you.

I'm interested Call 1-877-513-1460
Reasons to consider

Why people take part in clinical studies.

  • 01

    A possible new treatment option 1

    The UPSTREAM MG study is evaluating an investigational medicine called telitacicept in adults with generalized myasthenia gravis (gMG). Telitacicept targets certain parts of the immune system involved in antibody production. It is being studied to learn more about its safety and effectiveness for adults living with gMG.

    Telitacicept is investigational and has not been approved by the FDA for gMG.

  • 02

    Close medical care and follow-up 1,2

    If you qualify and take part, you may receive close medical care and study-related follow-up throughout your time in the study. The exact visit schedule will be explained by the study team, but you can expect regular visits during screening and treatment, with possible home injections between some on-site visits.

  • 03

    Contributing to research 2

    Clinical studies rely on people who are willing to take part. By joining, participants help researchers learn more about potential new treatments for gMG—knowledge that may help others living with gMG in the future.

Your rights

You decide, at every step.

Joining a clinical trial is voluntary. Deciding not to take part will not affect your usual medical care now or in the future. Clinical studies are reviewed and overseen by independent ethics committees to help protect participant safety.

All medicines and clinical studies have possible risks, including side effects. The study team will review the known and potential risks and benefits with you before you decide whether to join.

  • Joining a clinical trial is voluntary. It is your choice whether to take part.

  • Deciding not to take part will not affect your usual medical care now or in the future.

  • If you join, you can leave the study at any time and for any reason.

  • Clinical studies are reviewed and overseen by independent ethics committees to help protect participant safety.

An older adult in a quiet moment of care with a family member.
A word from a researcher
“While we now have several biologic therapies for MG, I'm excited to explore an investigational product that may present a more upstream treatment of gMG.”

— Tuan Vu, MD

Principal Investigator, UPSTREAM MG trial

Learn about the condition

Want to understand gMG in plain language first?

Read about generalized myasthenia gravis

References

Medically reviewed · May 2026

  1. A study of telitacicept for the treatment of generalized myasthenia gravis (UPSTREAM MG). ClinicalTrials.gov identifier: NCT06456580. Updated May 7, 2026. Accessed May 14, 2026. https://clinicaltrials.gov/study/NCT06456580
  2. Clinical research: why take part? Johns Hopkins Medicine. Accessed May 14, 2026. https://www.hopkinsmedicine.org/research/understanding-clinical-trials/why-take-part
Ready when you are

Ready to take the next step?

Registering takes about a minute and is not a commitment to join the study.

I'm interested Call 1-877-513-1460
I'm interested